Systemic Anti Cancer Therapy Protocols

These clinical protocols have been developed by local clinicians, with the support of the South West Strategic Clinical Network (SWSCN). The information is provided as guidance only, and has no legal or official standing. The guidance does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of each patient, in consultation with the patient and/or their guardian or carer. Availability of treatments may change, subject to NHS funding agreements. These protocols must be used in conjunction with local and national commissioning guidance.

The protocols are still being updated and more will be added to this website as they are completed. If you have any queries or suggestions, or would like to be involved in the development of these protocols please contact us

Oncology

Cancer of Unknown Primary

The site specific chemotherapy protocols on the SWCN website can be used for CUP patients, as agreed by the CUP MDT.

The most frequently used protocols are listed below​:
Carboplatin and Etoposide (SCLC) (as per Lung Cancer Protocol)
Carboplatin and Paclitaxel (as per Gynae Cancer protocol)
Gemcitabine and Capecitabine (pancreas) (as per Upper GI protocol)
Gemcitabine and Carboplatin (as per Lung Cancer protocol)
Epirubicin, Cisplatin and Capecitabine (ECX – oesophagus) (as per Upper GI protocol)
Epirubicin, Oxaliplatin and Capecitabine (EOX – oesophagus) (as per Upper GI protocol)
Paclitaxel weekly (as per Gynae protocol)

Haematology

Leukaemia

Acute Myeloid Leukaemia

Arsenic trioxide
ATRA
Azacitidine
Clofarabine and Cytarabine
FLAG/IDA
Midostaurin

Acute Lymphocytic Leukamia

Blinatumomab
Inotuzumab
Nelarabine

Chronic Myeloid Leukaemia

Bosutinib
Dasatinib
Hydroxycarbamide
Imatinib
INF
Nilotinib
Ponatinib

Hairy Cell Leukaemia

Cladribine

Myeloproliferative disorders

ATG
Azacitidine
Busulphan
Hydroxycarbamide
Ruxolitinib

Supportive Therapy

Denosumab
Zoledronic Acid

Guidelines

 

Archived Protocols

Lapatinib and Capecitabine
Topotecan
Carboplatin, Gemcitabine and Bevacizumab