Systemic Anti Cancer Therapy Protocols

These clinical protocols have been developed by local clinicians, with the support of the South West Clinical Network (SWCN). The information is provided as guidance only, and has no legal or official standing. The guidance does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of each patient, in consultation with the patient and/or their guardian or carer. Availability of treatments may change, subject to NHS funding agreements. These protocols must be used in conjunction with local and national commissioning guidance.

The protocols are still being updated and more will be added to this website as they are completed. If you have any queries or suggestions, or would like to be involved in the development of these protocols please contact us


Cancer of Unknown Primary

The site specific chemotherapy protocols on the SWCN website can be used for CUP patients, as agreed by the CUP MDT.

The most frequently used protocols are listed below​:
Carboplatin and Etoposide (SCLC) (as per Lung Cancer Protocol)
Carboplatin and Paclitaxel (as per Gynae Cancer protocol)
Gemcitabine and Capecitabine (pancreas) (as per Upper GI protocol)
Gemcitabine and Carboplatin (as per Lung Cancer protocol)
Epirubicin, Cisplatin and Capecitabine (ECX – oesophagus) (as per Upper GI protocol)
Epirubicin, Oxaliplatin and Capecitabine (EOX – oesophagus) (as per Upper GI protocol)
Paclitaxel weekly (as per Gynae protocol)


Supportive Therapy

Zoledronic Acid


Bone Protection Myeloma 2018

Archived Protocols

Docetaxel, Doxorubicin and Cyclophosphamide (TAC)
Lapatinib and Capecitabine
Carboplatin, Gemcitabine and Bevacizumab